منابع مشابه
Physiological models of leptin resistance.
In common forms of obesity, animals and humans become leptin resistant associated with impaired regulation of energy homeostasis. Over the last decade, significant advances in delineating the underlying mechanisms have been achieved. As well as the obvious scientific progress obtained by novel transgenic animals, natural and physiological models of leptin resistance such as the Siberian hamster...
متن کاملYOUNG INVESTIGATOR PERSPECTIVE Physiological Models of Leptin Resistance
The discovery of leptin revolutionised the field of obesity research since this hormone represents the long postulated ‘adiposity signal’ that provides the afferent signal required for the lipostatic theory (1), conveying information about the status of body fat stores to the brain. Despite the outstanding anorexigenic potential of leptin, catabolic effects are not always apparent. Since circul...
متن کاملLeptin receptor signaling: pathways to leptin resistance.
The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status. In the hypothalamus, leptin triggers specific neuronal subpopulations, like POMC and AgRP/NPY neuron...
متن کاملMammary leptin synthesis, milk leptin and their putative physiological roles.
This paper reviews data on mammary leptin and leptin receptor gene expression as well as on blood and milk leptin levels during the pregnancy-lactation cycle in humans, rodents and ruminants, with the aim of better understanding milk leptin origin and functions. The few published papers report that leptin may be produced by different cell types in the mammary tissue, and may act as a paracrine ...
متن کاملMechanisms of leptin action and leptin resistance.
The adipose tissue-derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity defines a state of so-called leptin resistance....
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ژورنال
عنوان ژورنال: Medycyna Weterynaryjna
سال: 2016
ISSN: 0025-8628
DOI: 10.21521/mw.5576